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Drug Interactions With Estradiol Valerate

Estradiol Valerate Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when estradiol valerate is combined with any of the drugs listed above.
Barbiturate Medications
Barbiturates may cause your body to metabolize the hormones in estradiol valerate too rapidly, leading to low levels of estradiol valerate in the body. This can make estradiol valerate less effective, but it is not a serious drug interaction.
Certain Antifungals or Antibiotics
Some antibiotic or antifungal medications may decrease the ability of your liver to metabolize estradiol valerate, leading to high levels of estradiol valerate in the body. This may increase the risk of estradiol valerate side effects. Check with your healthcare provider before combining estradiol valerate with certain antibiotics or antifungals.
Certain Seizure Medications
Some seizure medications may cause your body to metabolize the hormones in estradiol valerate too quickly, leading to low levels of estradiol valerate in the body. Although this can make estradiol valerate less effective, it is not a dangerous drug interaction.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Estradiol valerate may increase the level of cyclosporine in your blood, increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to one of the many estradiol valerate alternatives.
Protease Inhibitors
Protease inhibitors may decrease the ability of your liver to metabolize estradiol valerate, leading to high levels of estradiol valerate in the body. This may increase the risk of estradiol valerate side effects. Check with your healthcare provider before combining estradiol valerate with a protease inhibitor.
Last reviewed by: Kristi Monson, PharmD
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