Drug Interactions With Estradiol Valerate

Several medications can cause drug interactions with estradiol valerate, including barbiturates, certain antibiotics, and some thyroid medications. These interactions can potentially increase your risk of developing side effects or decrease the effectiveness of estradiol valerate. If estradiol valerate drug interactions are a concern, your healthcare provider may monitor you more closely and adjust your dosages.

An Introduction to Drug Interactions With Estradiol Valerate

Estradiol valerate (Delestrogen®) has the potential to interact with numerous other medications, even though it is not taken by mouth. However, not all of the estradiol valerate drug interactions are serious. Some of the medicines that may lead to estradiol valerate interactions include:
  • Barbiturates, including (but not limited to):


    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
  • Certain antifungal medications or antibiotics, such as:


    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)
  • Certain seizure medications, such as:



  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • St. John's wort (Hypericum perforatum), an herbal supplement
  • Thyroid replacement medications, including:


Last reviewed by: Kristi Monson, PharmD
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