Estradiol Valerate

Storage Methods

Estradiol valerate should be stored at room temperature, away from moisture and heat. Keep this and all other medications out of the reach of children.

What If I Miss a Dose?

If you are late for a dose of estradiol valerate, simply contact your healthcare provider to schedule your next injection as soon as possible.

How Does Estradiol Valerate Work?

Estradiol valerate contains estradiol, a hormone that is the predominant estrogen in premenopausal women. This medication helps to relieve menopausal symptoms by replacing the estrogen that the ovaries no longer produce.
Very high doses of estrogens (such as estradiol valerate) can work to relieve the symptoms of advanced prostate cancer. For prostate cancer, estradiol valerate works by suppressing testosterone and other male hormones that "feed" prostate cancer.
Estradiol valerate is formulated in oil to make the injection long-acting.

When and How to Use It

Some general considerations for when and how to use this medication include the following:
  • Estradiol valerate is injected into a muscle, usually once a month (although it can be used as frequently as once a week for prostate cancer).
  • Your healthcare provider will administer the estradiol valerate injection, as it must be injected into the gluteal muscle (a muscle of the buttocks).
  • For the medication to work properly, it must be taken as prescribed.

Who Makes Estradiol Valerate?

Estradiol valerate is made by JHP Pharmaceuticals, LLC. It is sold under the brand name Delestrogen. Generic estradiol valerate is available and is made by Sandoz (see Generic Delestrogen for more information).
Last reviewed by: Kristi Monson, PharmD
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