Precautions and Warnings With Estradiol Valerate

Before starting a new drug, it is important to understand its precautions and warnings. With estradiol valerate, it is important to be aware of potential drug interactions and to let your healthcare provider know if you have certain health conditions. For example, estradiol valerate can make certain conditions worse, such as diabetes, epilepsy, and asthma. Also, you should not take estradiol valerate if you have undiagnosed abnormal genital bleeding, liver disease, or a history of breast cancer.

Estradiol Valerate Information

Estradiol Valerate: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using estradiol valerate (Delestrogen^®) if you have:

Unexplained abnormal vaginal bleeding
Heart disease or heart problems of any kind
Cancer (or a history of cancer) of any kind
Had a heart attack, blood clot, or stroke
High blood pressure, high cholesterol, or high triglycerides
Gallbladder disease
Diabetes
Liver disease, such as liver failure, cirrhosis, hepatitis, or liver tumors
Asthma
Seizures or epilepsy
Had yellowing of the whites of the eyes or skin (jaundice) during a prior pregnancy or estrogen use
Systemic lupus erythematosus (SLE, or lupus)
Migraine headaches
Kidney disease, including kidney failure (renal failure)
An underactive thyroid (hypothyroidism)
Endometriosis
Any allergies, including allergies to drugs, foods, preservatives, or dyes.

Also, let your healthcare provider know if you:

Are pregnant or thinking of becoming pregnant
Are breastfeeding
Have an upcoming surgery
Smoke cigarettes.

Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

(Precautions and Warnings With Estradiol Valerate Continued: Page 2)