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What Is Estradiol Valerate Used For?

Estradiol valerate is primarily used for treating several conditions associated with estrogen hormones. Specifically, estradiol valerate is approved to treat menopausal symptoms and hormone deficiencies, and can also help relieve the symptoms of advanced prostate cancer. In some cases, healthcare providers can also prescribe this medication for other uses. Estradiol valerate can be used "off-label" for men who are undergoing a sex change.

What Is Estradiol Valerate Used For?

Estradiol valerate (Delestrogen®) is a prescription medication that contains an estrogen hormone. It is approved for the following uses:
  • Treatment of menopausal symptoms, such as hot flashes, night sweats, and vaginal symptoms
  • Treatment of hormone deficiency in younger women whose ovaries do not produce enough estrogen (or who have had their ovaries removed)
  • Reduction of the symptoms of advanced prostate cancer.

Estradiol Valerate Use for Menopause

Menopause is a normal change in a woman's life when she stops having her period. Technically, a woman has reached menopause when she has not had a period for 12 months in a row and there are no other causes for this change. Menopause symptoms include:
  • Hot flashes (hot flushes)
  • Night sweats and sleeping problems (including insomnia)
  • Vaginal changes, such as dryness or irritation
  • Changes in your period, including abnormal bleeding or "spotting"
  • Thinning and weakening of your bones
  • Problems with concentration or memory
  • Less interest in sex and changes in sexual response
  • Mood changes
  • Urinary problems
  • Weight gain or an increase in body fat around your waist
  • Hair thinning or loss.
For some women, these symptoms are quite severe, and some form of menopause relief may be necessary. This may include medications, natural menopause relief remedies, or non-medical ways to deal with the symptoms. Estradiol valerate is approved to treat moderate to severe vasomotor symptoms, which include hot flashes and night sweats. It is also used to treat vaginal symptoms, such as irritation and dryness.
For menopause treatment, estradiol valerate should be used at the lowest effective dose for the shortest period of time necessary.
Last reviewed by: Kristi Monson, PharmD
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