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Drug Interactions With Estropipate

Protease Inhibitors
Protease inhibitors may decrease the ability of your liver to metabolize estropipate, possibly leading to high levels of estropipate in the body. This may increase the risk of estropipate side effects. Check with your healthcare provider before combining these medications.
Rifamycin Antibiotics
Rifamycin antibiotics may cause your body to metabolize the hormones in estropipate too quickly, possibly leading to low levels of estropipate in the body. Although this can make estropipate less effective, it is not a dangerous drug interaction.
St. John's Wort
St. John's wort (a commonly used herbal supplement) may cause your body to metabolize the hormones in estropipate too quickly, possibly leading to low levels of estropipate in the body. Although this can make estropipate less effective, it is not a dangerous drug interaction.
Thyroid Replacement Medications
If you take medications for an underactive thyroid (hypothyroidism) with estropipate, your healthcare provider may need to increase the dose of your thyroid medication. Your healthcare provider should monitor you and make any necessary dosing adjustments.

Final Thoughts on Estropipate Drug Interactions

It is possible that not every drug interaction was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the drug interactions with estropipate that may apply to you.
Last reviewed by: Kristi Monson, PharmD
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