Estropipate Dosage

For most women, the recommended estropipate dosage for menopausal symptoms is 0.625 mg once daily. For estrogen replacement in younger women who have low estrogen levels, the recommended dose is 1.25 mg once daily. Your healthcare provider can increase these doses if needed. The usual estropipate dose for the prevention of osteoporosis in postmenopausal women is 0.625 mg once daily, taken cyclically.

Estropipate Dosage: An Introduction

The dose of estropipate (Ogen®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The medical condition being treated
  • How you respond to estropipate
  • Whether you have had a hysterectomy
  • Other medical conditions you may have.
As always, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Estropipate Dosing for Osteoporosis Prevention

For preventing osteoporosis in postmenopausal women, the recommended dose of estropipate is 0.625 mg once daily, taken cyclically (25 days on, 6 days off).

Estropipate Dosing for Menopause

When using estropipate for menopausal symptoms, women are often recommended to take it at the lowest effective dose for the shortest possible time. However, the most effective dose (and how long it should be taken) can vary considerably from one woman to the next. For most women, the recommended starting estropipate dose is 0.625 mg once daily. If necessary, your healthcare provider may increase your dose up to estropipate 5 mg once daily.
The medication is approved for cyclic use, such as three weeks on and one week off. Taking it cyclically can help promote regular, menstrual-like bleeding and decrease breakthrough bleeding, especially in younger women. Some healthcare providers may also recommend continuous use of estropipate (every single day without any breaks). Taking it continuously can result in a complete absence of bleeding, especially in older women, a side effect that many women desire.
If you still have a uterus, you must take estropipate with a progestin hormone in order to reduce the risk of precancerous and cancerous uterine changes. The progestin can be taken every day or for just a certain part of the cycle (often the last half of each cycle). If you have had a hysterectomy, you do not have to take progesterone along with estropipate.
Last reviewed by: Kristi Monson, PharmD
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