How Does Estropipate Work?

Estropipate is an estrogen medication. It helps relieve menopausal symptoms by replacing the estrogen that the ovaries no longer produce. Because estrogen helps keep the bones strong, the decrease during menopause causes a significant weakening of the bones, often resulting in osteoporosis. By providing estrogen, estropipate can help prevent these menopause-related bone changes.

When and How to Use This Medication

General considerations for when and how to use estropipate include the following:
  • The medication comes in tablet form. It is taken by mouth once a day.
  • You can take estropipate with or without food. If the drug bothers your stomach, try taking it with food (some women find estrogens irritating to the stomach).
  • Estropipate is usually taken cyclically, with regular breaks to allow for period-like bleeding. Your healthcare provider will help you decide exactly how to take the drug.
  • It does not matter what time of day you take estropipate, although you should take it at the same time each day.
  • The tablets can be broken in half if necessary to achieve the right dose.
  • For the medication to work properly, it must be taken as prescribed.

Dosing Information

The dose of estropipate your healthcare provider recommends will vary, depending on a number of factors, including:
  • The medical condition being treated
  • How you respond to estropipate
  • Whether you have had a hysterectomy
  • Other medical conditions you may have.
As always, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
(Click Estropipate Dosage for more information.)
Last reviewed by: Kristi Monson, PharmD
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