Side Effects of Estropipate

Common Side Effects of Estropipate

Common side effects of estrogen medications such as estropipate include but are not limited to:
  • Headaches
  • Irregular vaginal bleeding or spotting
  • Breast tenderness
  • Abdominal (stomach) cramps or bloating
  • High blood sugar (hyperglycemia)
  • Fluid retention
  • Nausea and vomiting
  • Hair loss
  • High blood pressure
  • Enlargement of benign tumors of the uterus (uterine fibroids)
  • Vaginal yeast infections.

Final Thoughts on Estropipate Side Effects

You may experience some or none of the estropipate side effects listed in this article. Unfortunately, it can be difficult to tell whether any particular side effect (such as nausea) is caused by estropipate or other factors. Therefore, make sure to let your healthcare provider know if you develop any side effects while taking the drug or if something "just does not seem right." While it may not be a side effect of the medication, your healthcare provider will be able to diagnose and treat the problem.
Last reviewed by: Kristi Monson, PharmD
Calcium and Strong Bones