Side Effects of Estropipate

Although most women do not experience problems with estropipate, side effects are possible. Common side effects that have been reported with estrogen medications such as estropipate include breast tenderness, high blood pressure, and fluid retention. Other side effects of estropipate, while rare, are potentially serious and should be reported to your healthcare provider, including heavy vaginal bleeding, chest pain, or breast lumps.

An Introduction to Estropipate Side Effects

As with any medicine, side effects are possible with estropipate (Ogen®). However, not everyone who takes the drug will experience side effects. In fact, most women tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with estropipate. Your healthcare provider can discuss a more complete list of estropipate side effects with you.)

Serious Side Effects Seen With Estropipate

Some side effects of estrogens (such as estropipate) are rare, but are serious enough to mention. These side effects include:
Because of the potentially serious nature of these side effects, there are a few symptoms you should watch for and report to your healthcare provider immediately if they occur. These include but are not limited to:
  • Breast lumps or other unusual breast changes
  • Heavy vaginal bleeding or unexpected vaginal bleeding
  • Signs of a blood clot in the leg, such as:
    • Pain in the calf
    • Leg cramps
    • Leg or foot swelling
  • Signs of a blood clot in the lung, such as:
    • Shortness of breath
    • Sharp chest pain
    • Coughing up blood
    • Vision or speech changes
    • Weakness or numbness in an arm or leg
    • Severe headache
  • Chest pain or heaviness, which may be signs of a heart attack
  • Sudden loss of vision or vision changes, which can be a sign of a blood clot in the eye
  • Signs of liver damage, such as:
    • Yellowing of the whites of the eyes or skin (jaundice)
    • Dark urine
    • Upper-right abdominal pain (stomach pain)
  • Migraines (or changes in your migraines, if you have had them before)
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Wheezing
    • Difficulty breathing or swallowing.
Last reviewed by: Kristi Monson, PharmD
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