What Is Estropipate Used For?

Estropipate Uses for Osteoporosis
Because estrogen helps keep bones strong, the decrease during menopause causes a significant weakening of the bones, often resulting in osteoporosis. By providing estrogen, estropipate can help prevent these menopause-related bone changes. However, the drug is not risk-free and should only be used in women who cannot use other, non-hormonal medications for osteoporosis prevention.
Estropipate Use in Younger Women
Sometimes, younger women do not produce enough estrogen, for a variety of reasons. In some cases, for unknown reasons, the ovaries simply stop working too soon. In other instances, certain medications (such as chemotherapy) affect the ability of the ovaries to function properly. Some women have had their ovaries surgically removed. Or, perhaps, the ovaries never started working properly in the first place, which results in delayed or absent puberty. In all of these situations, estropipate can be used as a substitute for the estrogen that the ovaries do not produce.

Estropipate Use in Children and Teens

Estropipate is not approved for use in children or teens. Discuss the risks and benefits of using the drug with your child's healthcare provider.

Off-Label Estropipate Uses

On occasion, your healthcare provider may recommend estropipate for something other than the conditions discussed in this article. This is called an "off-label" use. At one point, hormone replacement therapy was used off-label for preventing heart disease and dementia (such as Alzheimer's disease), but these are no longer considered legitimate off-label uses. Sometimes hormones are used to promote youthfulness. Again, this is not generally accepted as a legitimate off-label estropipate use.

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Last reviewed by: Kristi Monson, PharmD
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