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Hydroxyprogesterone Caproate Dosage

Hydroxyprogesterone caproate is given as a weekly injection. The recommended dosage is the same for all women -- 250 mg (1 mL) injected intramuscularly every seven days. Your healthcare provider will give you more specific dosing guidelines for using hydroxyprogesterone caproate, such as when in your pregnancy this treatment should be started.

An Introduction to Your Dose of Hydroxyprogesterone Caproate

There is only one standard dosage for hydroxyprogesterone caproate (Makena™), regardless of your age or weight, although there is some variability as to when exactly in pregnancy the drug is started. As is always the case, do not adjust your dose unless your healthcare provider specifically tells you to do so.

Hydroxyprogesterone Caproate Dosing Guidelines

The usual recommended dose of hydroxyprogesterone caproate is 250 mg (1 mL) injected into a muscle (intramuscularly) once every seven days. It is usually started between 16 and 21 weeks of pregnancy and continued to 37 weeks of pregnancy (up to 36 weeks, 6 days) or until delivery, whichever is first.
Each vial of hydroxyprogesterone caproate contains five doses (5 mL). The entire vial must be used within five weeks, which is not a problem if you stay on track with your injections.

General Information on Using Hydroxyprogesterone Caproate

Some considerations for women to keep in mind when receiving hydroxyprogesterone caproate include the following:
  • This medication comes as an injection. It is injected by a healthcare provider once a week (once every seven days). Hydroxyprogesterone caproate is not intended for self-injection.
  • The injections are given in the upper-outer area of the buttocks, near the hip.
  • For the medication to work properly, it must be given as prescribed.
  • If you are unsure about anything related to your hydroxyprogesterone caproate dose, please talk with your healthcare provider, nurse, or pharmacist.
Last reviewed by: Kristi Monson, PharmD
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