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Hydroxyprogesterone Caproate Injection

Available in the form of an injection, hydroxyprogesterone caproate (Makena™) is a drug used to help prevent premature birth. It is approved for women who have spontaneously delivered too early in a prior pregnancy.
Your healthcare provider will inject hydroxyprogesterone caproate once every seven days. Treatment typically starts between 16 and 21 weeks of pregnancy and is continued until 37 weeks of pregnancy or until delivery, whichever comes first.
This medication is not commercially available in generic form. However, some compounding pharmacies may make their own versions. These compounded injections cost much less than the brand-name drug and have been used for a long time to help prevent preterm birth.
(Click Hydroxyprogesterone Caproate for a closer look at how this injection is used. This article gives a complete overview of things you should be aware of before starting treatment, including side effects and safety issues to discuss with your healthcare provider.)
Last reviewed by: Kristi Monson, PharmD
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