Precautions and Warnings With Hydroxyprogesterone Caproate

If you have diabetes, you may need to monitor your blood sugar more closely during treatment with hydroxyprogesterone caproate. Other warnings and precautions for this drug relate to things like being aware of drug interactions, reporting any problems (such as vision changes) to your healthcare provider right away, and avoiding the medication altogether if you have certain medical conditions.

What Should I Tell My Healthcare Provider?

Talk with your healthcare provider prior to receiving hydroxyprogesterone caproate (Makena™) if you have:
Make sure to tell your healthcare provider about any medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Hydroxyprogesterone Caproate Warnings and Precautions

Some warnings and precautions to be aware of prior to using hydroxyprogesterone caproate include the following:
  • Hydroxyprogesterone caproate can cause fluid retention (water weight gain), which can cause problems for women with seizures, epilepsy, migraines, heart problems, or kidney disease.
  • Let your healthcare provider know if you have depression or a history of depression, as hydroxyprogesterone caproate could make depression worse.
  • Let your healthcare provider know right away if you have any vision changes or if you get a migraine for the first time while using hydroxyprogesterone caproate.
  • If you have diabetes, your healthcare provider may recommend that you monitor your blood sugar more closely when starting or stopping this medication in case you experience any changes in your blood sugar.
  • If you develop a blood clot while using hydroxyprogesterone caproate, your healthcare provider will probably recommend that you stop using the drug.
  • If you develop yellow skin (jaundice) or high blood pressure while using this medicine, your healthcare provider will monitor you closely in order to determine if you should keep using it.
  • Hydroxyprogesterone caproate can react with a few different medications (see Drug Interactions With Hydroxyprogesterone Caproate for more information).
  • Although hydroxyprogesterone caproate is intended for use during pregnancy, it is classified as a pregnancy Category B medication, which means that it is probably safe for use during pregnancy, although the full risks are currently unknown. It was given this rating mostly because the safety of the drug during the first trimester is unclear at this point(see Makena and Pregnancy).
  • The hormones in hydroxyprogesterone caproate pass through breast milk. Therefore, if you are still breastfeeding, discuss this with your healthcare provider prior to using the drug (see Makena and Breastfeeding).

More Headlines in Precautions and Warnings With Hydroxyprogesterone Caproate

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Last reviewed by: Kristi Monson, PharmD
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