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LaViv Uses

LaViv is approved for the treatment of "smile lines." As people age, they lose collagen; this can result in facial folds and wrinkles. LaViv contains a person's own cells, which are multiplied in a laboratory and then injected back into the skin. In some cases, a healthcare provider may recommend using LaViv off-label, such as when treating facial folds other than smile lines.

What Is LaViv Used For?

LaViv™ (azficel-T) is a personalized cell therapy product used for cosmetic purposes. The medication is approved to treat "nasolabial folds."
One of the main causes of facial folds and wrinkles is the natural loss of collagen that occurs as people age. Collagen provides structure to the skin, helps to promote skin elasticity, and helps the skin to retain moisture, improving the appearance of smile lines. LaViv is specifically created for each user, using skin cells obtained through a skin biopsy.
LaViv is not for people who desire instant results, as it can take as long as six months for the product to be created. After that, it takes three treatment sessions -- each three to six weeks apart -- to finish the treatment. Even then, improvement can be gradual.
Not all healthcare providers are qualified to use this product; only those who have completed a training program can do so. Also, keep in mind that sometimes the laboratory cannot make enough of the product, and another biopsy may need to be performed.
Studies have shown the effects of LaViv to last at least six months. It is unclear, at this point, how much longer they last. It is possible that additional treatments will be needed to maintain the desired effects.

How Does LaViv Work?

It is not entirely clear how LaViv works. Since it contains mostly fibroblasts, at least theoretically, it makes sense that LaViv works by increasing collagen production since fibroblasts are responsible for making collagen.
Last reviewed by: Kristi Monson, PharmD
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