Drug Interactions With Leena

Certain medications may cause negative interactions if they are taken with Leena. Drug interactions with Leena may occur if this birth control pill is taken with barbiturates, antibiotics, or certain seizure medications, to name a few. Some of these interactions can decrease the effectiveness of Leena, increasing your risk of pregnancy. These interactions may also increase your risk of certain side effects.

An Introduction to Drug Interactions With Leena

Leena® (norethindrone/ethinyl estradiol) can potentially interact with many other medicines. A number of these interactions can be quite severe and may even lead to accidental pregnancy. In these instances, a backup method of birth control may be required, in order to prevent pregnancy. If you do not know what to do about a Leena drug interaction, make sure to use a backup method of birth control until you can speak with your healthcare provider.
Some of the medicines that may lead to Leena interactions include:
  • Aminoglutethimide (Cytadren®)
  • Antibiotics
  • Aprepitant (Emend®)
  • Barbiturates, including, but not limited to:


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)



(Leena is a generic version of Tri-Norinyl® and is also equivalent to Aranellebirth control pills. The information in this article also applies to each of these medications.)
Last reviewed by: Kristi Monson, PharmD
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