Drug Interactions With Leuprolide Acetate Depot

By Susan Lakey, PharmD, MPH |

Diabetes medications, such as metformin, insulin, sulfonylureas, and alpha-glucosidase inhibitors, are the only products expected to cause drug interactions with leuprolide acetate depot. If you have diabetes, your healthcare provider may adjust the doses of your diabetes medications and have you check your blood sugar more often during treatment with leuprolide acetate depot.

An Overview of Leuprolide Acetate Depot Interactions

Leuprolide acetate depot (Lupron Depot^®) is a prescription hormone medication that is given as an injection. Leuprolide acetate depot is not expected to interact with most medications. However, it may react with drugs used to treat diabetes, including:

Alpha-glucosidase inhibitors, such as:
- Acarbose (Precose^®)
- Miglitol (Glyset^®)

Dipeptidyl peptidase-4 (DPP-4) inhibitors, such as:
- Alogliptin (Nesina^®), alogliptin and metformin (Kazano^®), and alogliptin and pioglitazone (Oseni^®)
- Linagliptin (Tradjenta™)
- Linagliptin and metformin (Jentadueto™)
- Saxagliptin (Onglyza™)
- Sitagliptin (Januvia^®)
- Sitagliptin and metformin (Janumet^®)
- Sitagliptin and metformin XR (Janumet^® XR)

Glitazones and glitazone combination medications, such as:
- Pioglitazone hydrochloride (Actos^®)
- Pioglitazone and glimepiride (Duetact^®)
- Pioglitazone and metformin (Actoplus Met^®)
- Pioglitazone and metformin XR (Actoplus Met^® XR)
- Rosiglitazone (Avandia^®)
- Rosiglitazone and glimepiride (Avandaryl^®)
- Rosiglitazone and metformin (Avandamet^®)

Glucagon-like peptide 1 receptor agonists, such as:
- Exenatide (Byetta^®)
- Liraglutide (Victoza^®)

Insulin of any type
Meglitinides, such as:
- Nateglinide (Starlix^®)
- Repaglinide (Prandin^®)

Metformin (Glucophage^®, Glucophage XR^®, Fortamet^®, Glumetza^®, Riomet^®)
Sulfonylureas or sulfonylurea combination medications, such as:
- Chlorpropamide (Diabinese^®)
- Glimepiride (Amaryl^®)
- Glimepiride and pioglitazone (Duetact^®)
- Glimepiride and rosiglitazone (Avandaryl^®)
- Glipizide (Glucotrol^®, Glucotrol XL^®)
- Glipizide and metformin (Metaglip^®)
- Glyburide (DiaBeta^®, Micronase^®, Glynase^®)
- Glyburide and metformin (Glucovance^®)
- Tolazamide (Tolinase^®)
- Tolbutamide (Orinase^®).

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Last reviewed by: Kristi Monson, PharmD

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Leuprolide Acetate Depot Guide

‣ Leuprolide Acetate Depot
‣ Leuprolide Acetate Depot Side Effects
‣ What Is Leuprolide Acetate Depot Used For?
‣ Leuprolide Acetate Depot Dosage
‣ Drug Interactions With Leuprolide Acetate Depot

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References

Lupron Depot 7.5 mg [package insert]. North Chicago, IL: Abbott Laboratories;2013 July.

Lupron Depot-Ped (3-month) [package insert]. North Chicago, IL: Abbott Laboratories;2011 August.

Lupron Depot 7.5 mg [package insert]. North Chicago, IL: Abbott Laboratories;2011 January.

Lupron Depot-3 Month Formulation 22.5 mg [package insert]. North Chicago, IL: Abbott Laboratories;2011 January.

Lupron Depot-4 Month Formulation 30 mg [package insert]. North Chicago, IL: Abbott Laboratories;2011 January.

Lupron Depot-Ped [package insert]. North Chicago, IL: Abbott Laboratories;2010 September.

Lupron Depot 3.75 mg [package insert]. North Chicago, IL: Abbott Laboratories;2010 October.

Lupron Depot-3 Month Formulation 11.25 mg [package insert]. North Chicago, IL: Abbott Laboratories;2010 October.

Lexi-Interact [computer program]. Lexi-Comp, Inc.; June 10, 2011.

Drug Interactions With Leuprolide Acetate Depot

An Overview of Leuprolide Acetate Depot Interactions

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