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Leuprolide Acetate Depot Dosage

Leuprolide Acetate Depot Dosage for Central Precocious Puberty

The standard dose of leuprolide acetate depot for central precocious puberty (early puberty in children) is based on the child's body weight, and will vary from child to child. The usual initial amount of the pediatric version is as follows:
  • Children who weigh 25 kg or less (55 pounds or less) will receive 7.5 mg every four weeks
  • Children who weigh 25 to 37.5 kg (55 to 82.5 pounds) will receive 11.25 mg every four weeks
  • Children who weigh more than 37.5 kg (82.5 pounds) will receive 15 mg every four weeks.
Your child's healthcare provider will monitor your child's response to treatment after one or two months and increase the dose if needed. The amount may be increased by 3.75 mg no more often than every four weeks until a dose is found that adequately stops puberty.
Two new once-every-three months strengths of leuprolide acetate depot have been approved for use in children. These two strengths (11.25 mg and 30 mg) are given once every 12 weeks. No weight-based dosing guidelines are available for these products.
Once an adequate dose is found, your child may still require periodic adjustments as he or she grows. Your child's healthcare provider will continue to monitor your child's response to determine if an adjustment is needed. The leuprolide acetate depot injection should be stopped before age 11 in girls and age 12 in boys to allow for normal sexual maturation.

Dose of Leuprolide Acetate Depot for Endometriosis

Leuprolide acetate depot is available in one-month and three-month forms for endometriosis. The standard dosage will depend on the particular form used, as follows:
  • Leuprolide acetate depot 3.75 mg once a month
  • Leuprolide acetate depot 11.25 mg once every three months.
For the initial treatment of endometriosis, leuprolide acetate depot may be given alone or in combination with norethindrone acetate. The recommended length of treatment is six months.
If your symptoms recur after the initial six months, your healthcare provider may recommend a second six-month course of leuprolide acetate depot. The second six-month course should always be given with norethindrone acetate 5 mg. Norethindrone helps reduce the risk of bone thinning that occurs when leuprolide acetate depot is used long-term.
The individual leuprolide acetate depot dosage forms are not interchangeable. This means that, for example, the form of leuprolide acetate depot that is given every three months is not equivalent to the form that is given monthly, regardless of how often the medications are given.
Last reviewed by: Kristi Monson, PharmD
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