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Leuprolide Acetate Depot Dosage

Dose of Leuprolide Acetate Depot for Uterine Fibroids

Leuprolide acetate depot is available in one-month and three-month forms for uterine fibroids. The standard dosage will depend on the particular form used, as follows:
  • Leuprolide acetate depot 3.75 mg once a month
  • Leuprolide acetate depot 11.25 mg once every three months.
The recommended length of treatment for uterine fibroids is up to three months. If treatment beyond three months is desired, your healthcare provider will need to check your bone health before you are given additional dosages.
The individual leuprolide acetate depot dosage forms are not interchangeable. This means that, for example, the form of leuprolide acetate depot that is given every three months is not equivalent to the form that is given monthly, regardless of how often the medications are given.

General Information on Using Leuprolide Acetate Depot

Some considerations to keep in mind during treatment with leuprolide acetate depot include the following:
  • This medication is given as an intramuscular (into the muscle) injection every one to four months, depending on the particular product used. Make sure you know how often you should be receiving this medication.
  • The injection is normally given by your healthcare provider in a healthcare setting. If you are giving the injection to yourself or your child, your healthcare provider should show you exactly how to use it.
  • Be sure you know how often you are supposed to receive your doses. Try not to miss any of your healthcare appointments.
  • Leuprolide acetate depot comes in a powder form that is mixed into a liquid right before use. Any medicine not used immediately must be thrown out.
  • For this drug to work properly, it must be taken as prescribed. Your symptoms will likely return when you stop using this medicine.
  • If you are unsure about anything related to dosing with leuprolide acetate depot, please talk with your healthcare provider, nurse, or pharmacist.
Last reviewed by: Kristi Monson, PharmD
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