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What Is Leuprolide Acetate Depot Used For?

Using Leuprolide Acetate Depot for Endometriosis

Endometriosis is a medical condition in which tissue that normally lines the inside of the uterus (the endometrium) grows in other areas of the body, usually around the pelvic area on the ovaries, fallopian tubes, bowel, and bladder. In rare cases, the tissue can also spread beyond the pelvic region.
The displaced endometrial tissue, or endometrial growths or "implants," behave in the same way as the lining of the uterus. During the menstrual cycle, the tissue thickens in preparation for pregnancy and then breaks down and bleeds when pregnancy does not occur. However, because the endometrial growths have no way to leave the body, problems such as irritation and scarring can occur.
Not all women with endometriosis experience symptoms. However, when symptoms do occur, they may include:
  • Pain in the pelvis, abdomen (stomach), or lower back
  • Painful intercourse
  • Painful periods
  • Heavy bleeding during periods, or bleeding between periods
  • Infertility.
Leuprolide acetate depot can be used to relieve the pain from endometriosis and reduce endometrial growths. It does not make endometriosis go away. The medication can be used alone or in combination with norethindrone acetate, a progestin hormone.
Leuprolide acetate depot should not be used for longer than six months at first. Treatment may be repeated for an additional six months if symptoms recur. If treatment is repeated, it must include a combination of leuprolide acetate depot and norethindrone acetate.
Last reviewed by: Kristi Monson, PharmD
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