What Is Leuprolide Acetate Depot Used For?

Leuprolide acetate depot mimics the action of a naturally occurring hormone in the body that slows down or blocks the release of testosterone and estrogen. As a result, healthcare providers use leuprolide acetate depot to treat precocious puberty, advanced prostate cancer, uterine fibroids, and endometriosis. This medicine only works when given as an injection and should not be taken by mouth.

An Overview of Uses for Leuprolide Acetate Depot

Leuprolide acetate depot (Lupron Depot®) is a prescription hormone medication approved for use in the following conditions:
  • Advanced prostate cancer
  • Endometriosis (a condition in which endometrial tissue grows in other areas of the body)
  • Uterine fibroids (noncancerous tumors in the uterus)
  • Central precocious puberty (puberty that occurs too soon) in children.
Leuprolide acetate depot is given via an intramuscular injection, which is an injection into the muscle, every one to four months. It is not active if taken by mouth.

Using Leuprolide Acetate Depot for Advanced Prostate Cancer

Leuprolide acetate depot is indicated for the palliative treatment of advanced prostate cancer. Palliative cancer treatment helps reduce symptoms of cancer, but does not cure the condition.
Leuprolide acetate depot can help reduce prostate cancer symptoms, such as pain and difficulty urinating. It offers an alternative for men who cannot, or do not want to, take estrogen or have their testicles removed (called an orchiectomy).
Last reviewed by: Kristi Monson, PharmD
7 Tricks to Relieve Your Enlarged Prostate