Precautions and Warnings With Levonorgestrel-Releasing Intrauterine System

By reviewing the precautions and warnings with levonorgestrel-releasing intrauterine system before using this device, you can be watchful for signs of potentially dangerous pelvic infections and other complications. These safety issues can also help you and your healthcare provider determine whether this form of birth control is appropriate and safe for your situation. This product should not be used in women who have liver tumors or uterine fibroids.


What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using levonorgestrel-releasing intrauterine system (Mirena®, Skyla™) if you have:
  • Ever had or currently have pelvic inflammatory disease (PID)
  • Had a serious pelvic infection
  • Multiple sexual partners or if your partner has multiple sexual partners
  • A weakened immune system due to leukemia, human immunodeficiency virus (HIV), acquired immunodeficiency syndrome (AIDS), IV drug use, or any other cause
  • Cancer of the uterus or cervix
In addition, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
Last reviewed by: Kristi Monson, PharmD
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