Drug Interactions With Liothyronine

More Information on Interactions With Liothyronine

The following sections explain in detail the potentially negative interactions that can occur when liothyronine is combined with any of the drugs listed above.
Bile Acid Sequestrants
Bile acid sequestrants can bind to liothyronine in the digestive tract, preventing it from being absorbed into the body. Make sure to separate liothyronine and a bile acid sequestrant by at least four to five hours.
Calcium
Calcium can bind to liothyronine in the digestive tract, preventing it from being absorbed into the body. This interaction was discovered with a different thyroid medication, but it is thought that it probably occurs with liothyronine as well. Make sure to separate liothyronine and calcium by at least four hours.
Certain Seizure Medications
Taking liothyronine with some seizure medications may change the amount of liothyronine your body needs, and your healthcare provider may need to adjust your liothyronine dosage as a result.
Diabetes Medications
When you first start liothyronine (or increase your dose), your healthcare provider may need to increase the dose of your diabetes medications. Check with your healthcare provider before taking liothyronine if you are already taking diabetes medications.
Digoxin
Liothyronine can make digoxin less effective and may increase the toxic effect of digoxin, which can be dangerous. Check with your healthcare provider, as your digoxin dosage may need to be increased.
Estrogens
Estrogens can lower the level of liothyronine in your blood, perhaps making it less effective. Your healthcare provider may need to adjust your liothyronine dose if you start or stop taking an estrogen medication.
Last reviewed by: Kristi Monson, PharmD
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