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Lo/Ovral Drug Interactions

Lo/Ovral Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Lo/Ovral is combined with any of the drugs listed above. If you are unsure about any particular drug interaction, it is a good idea to use backup birth control until you can speak with your healthcare provider.
Aminoglutethimide (Cytadren)
Combining Lo/Ovral with aminoglutethimide may increase your risk of unintentional pregnancy. Talk with your healthcare provider before using these medications together. You may need to use a backup method of contraception, such as condoms.
Antibiotics
There have been reports of unintentional pregnancy occurring in women taking birth control pills with certain antibiotics. However, it is still uncertain how significant this interaction may be, since many of these cases may have been simply coincidence. Some antibiotics are more likely to cause problems than others. Ask your healthcare provider if you need a backup method of contraception any time you take an antibiotic.
Aprepitant (Emend)
Aprepitant may make Lo/Ovral less effective, perhaps increasing your chance of pregnancy. Talk with your healthcare provider before using these medications together. You may need to use a backup method of contraception.
Barbiturates
Barbiturates may cause your body to metabolize the hormones in Lo/Ovral too quickly, possibly increasing your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a barbiturate.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Lo/Ovral may increase the level of cyclosporine in your blood, potentially increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. Your cyclosporine dose may need to be reduced, or you may need to switch to a different method of contraception.
Last reviewed by: Kristi Monson, PharmD
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