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Loestrin Fe Drug Interactions

Loestrin Fe Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Loestrin Fe is combined with any of the drugs listed above.
Aminoglutethimide (Cytadren)
Taking Loestrin Fe with aminoglutethimide may increase your risk of unintentional pregnancy. Talk with your healthcare provider before using these medications together. You may need to use a backup method of contraception, such as condoms.
Antibiotics
There have been reports of accidental pregnancy occurring in women taking birth control pills with certain antibiotics. However, the significance of this interaction is still uncertain. Some antibiotics are more likely to cause problems than others. If you are taking an antibiotic, ask your healthcare provider if you need to use a backup method of contraception.
Aprepitant (Emend)
Aprepitant can make Loestrin Fe less effective, perhaps increasing your chance of pregnancy. Talk with your healthcare provider before using these medications together. You may need to use a backup method of contraception.
Barbiturates
Barbiturates may cause your body to metabolize the hormones in Loestrin Fe too quickly, possibly increasing your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a barbiturate.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Loestrin Fe may increase the level of cyclosporine in your blood, possibly increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to a different method of contraception.
Last reviewed by: Kristi Monson, PharmD
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