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Lorcaserin

Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to taking this medication if you have:
  • Congestive heart failure (CHF)
  • Heart valve problems
  • A slow heart rate (bradycardia)
  • Heart block (a type of arrhythmia)
  • Depression or other mood disorder
  • A history of suicide attempts or thoughts of suicide
  • Diabetes
  • Any problem with the shape of your penis, such as Peyronie's disease
  • Blood cell problems, such as sickle cell anemia, multiple myeloma, or leukemia
  • A history of a painful or prolonged erection that lasted for more than four hours (priapism)
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Lorcaserin to learn more, including information on who should not take the drug.)

How Does It Work?

The exact way that lorcaserin works to help with weight loss is unknown. What is known is that the drug binds to and activates a certain type of serotonin receptor in the brain (the serotonin 2c receptor). Serotonin is a neurotransmitter (brain chemical) that plays an important role in several areas, including mood, sleep, and appetite. It is thought that, by activating serotonin receptors, lorcaserin helps people eat less and feel full faster.
Last reviewed by: Kristi Monson, PharmD
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