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Lybrel Drug Interactions

Lybrel Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Lybrel is combined with any of the drugs listed above. Contact your healthcare provider if you are unsure of what to do about a drug interaction or if you take an interacting drug that requires the use of backup contraception. Your healthcare provider will instruct you on how long you should use a backup method (it may be longer than you think).
Aminoglutethimide (Cytadren)
Aminoglutethimide can make Lybrel less effective, possibly increasing your risk of pregnancy. Talk with your healthcare provider before using these medications together. You may need to use a backup method of contraception (such as condoms).
Antibiotics
There have been reports of accidental pregnancy occurring in women taking birth control pills and certain antibiotics. However, the significance of this interaction is still uncertain. Some antibiotics are more likely to cause problems than others. If you are taking an antibiotic, ask your healthcare provider if you need to use a backup method of contraception.
Aprepitant (Emend)
Aprepitant can make Lybrel less effective, perhaps increasing your chance of pregnancy. Talk with your healthcare provider before using these medications together. You may need to use a backup method of contraception.
Barbiturates
Barbiturates may cause your body to metabolize the hormones in Lybrel too quickly, increasing your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a barbiturate.
Certain Seizure Medications
Some seizure medications may cause your body to metabolize the hormones in Lybrel too quickly, increasing your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a seizure medication.
Last reviewed by: Kristi Monson, PharmD
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