Lybrel Side Effects

Bleeding and Spotting While on Lybrel

You will not have a regular, scheduled monthly period while taking Lybrel. However, you will probably have some bleeding and spotting (at irregular intervals). Almost all women will have irregular bleeding and spotting when first starting Lybrel. This tends to improve over time. In one study, after 13 months of taking Lybrel, 20 percent of women only had spotting, 21 percent had full bleeding (with or without spotting), and 59 percent had stopping bleeding and spotting altogether.
For many women, this unpredictable bleeding and spotting is bothersome enough to stop taking Lybrel. Keep in mind that it probably will improve, although some women will continue to spot and bleed.

Lybrel Side Effects to Report

There are a number of side effects with Lybrel that you should report to your healthcare provider. These include, but are not limited to:
  • Signs of a blood clot in the leg, such as pain in the calf, leg cramps, and leg or foot swelling
  • Signs of a blood clot in the lung, such as shortness of breath, sharp chest pain, or coughing up blood
  • Chest pain or heaviness, which may be signs of a heart attack
  • A sudden loss of vision or vision changes, which can be a sign of a blood clot in the eye
  • Signs of a stroke, such as vision or speech changes, weakness or numbness in an arm or leg, and a severe headache
  • Signs of liver damage, such as yellowing of the whites of the eyes or skin (jaundice), dark urine, and upper right abdominal pain (stomach pain)
  • Depression or other emotional changes
  • Migraines
  • Breast lumps
  • High blood pressure (hypertension)
  • High cholesterol
  • Signs of an allergic reaction, including an unexplained rash, hives, itching, unexplained swelling, wheezing, or difficulty breathing or swallowing.
Last reviewed by: Kristi Monson, PharmD
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