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Lysteda Drug Interactions

Certain medications are known to interact with Lysteda. For example, drugs such as Autoplex-T and hormonal contraceptives can increase your risk of blood clots if they are taken with Lysteda. Other medications that can cause problems when combined with Lysteda include Vesanoid and factor IX complex concentrates.

An Overview of Interactions With Lysteda

Lysteda™ (oral tranexamic acid) can potentially interact with a few other medications. Some of the medicines that may lead to drug interactions with Lysteda include (but are not limited to):
  • Alteplase (Activase®)
  • Anti-inhibitor coagulant concentrates (Autoplex-T, Feiba VH)
  • Factor IX complex concentrates
  • Hormonal contraceptives
  • Oral tretinoin (Vesanoid®).

Lysteda Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Lysteda is combined with any of the drugs listed above.
Alteplase
Lysteda and alteplase work in opposite ways. Taking them together may decrease the effectiveness of both medications.
Anti-inhibitor Coagulant Concentrates
It is not recommended that women take both an anti-inhibitor coagulant concentrate and Lysteda, as this combination increases the risk of blood clots.
Factor IX Complex Concentrates
It is not recommended for women to take both a factor IX complex concentrate and Lysteda, as this combination increases the risk of blood clots.
Hormonal Contraceptives
Both Lysteda and hormonal contraceptives can increase the risk of blood clots. Combined hormonal contraceptives (which contain both an estrogen and progestin component, and which include most birth control pills, patches, and rings) should not be used in combination with Lysteda.

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‣ Final Thoughts
Last reviewed by: Kristi Monson, PharmD
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