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Estradiol cypionate is a prescription medication approved to treat menopausal symptoms and estrogen deficiency. This medication contains an estrogen hormone and works by replacing the estrogen the ovaries no longer produce. It comes in the form of an injection and is taken every three to four weeks. Possible side effects include breast pain, nausea, and headaches.

What Is Estradiol Cypionate?

Estradiol cypionate (Depo®-Estradiol) is a prescription hormone replacement medication that contains estrogen. It comes as a long-acting injection that is injected into a muscle every three to four weeks. Estradiol cypionate is approved for the following uses:
  • Treating menopausal symptoms, such as hot flashes or night sweats
  • Replacing hormones in younger women whose ovaries do not produce enough estrogen or who have had their ovaries removed.
(Click What Is Estradiol Cypionate Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, estradiol cypionate can cause side effects. However, not everyone who uses the medication will experience problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious reactions are less common.
Common side effects of estrogen medications such as estradiol cypionate include but are not limited to:
  • Nausea and vomiting
  • Breast pain
  • Headaches
  • Abdominal pain (stomach pain)
  • Vaginal bleeding.
(Click Side Effects of Estradiol Cypionate to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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