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Estradiol vaginal cream is a hormone replacement therapy medication that is inserted vaginally. It is specifically used for treating vaginal menopause symptoms, such as dryness, itching, and burning in and around the vagina. Estradiol vaginal cream is available by prescription only and is generally used once a day until symptoms improve. Potential side effects of the hormone medication include bloating, headaches, and breast tenderness.

What Is Estradiol Vaginal Cream?

Estradioal vaginal cream (Estrace® Vaginal Cream) is a prescription medication that contains an estrogen hormone. It is used to treat dryness, itching, and burning in and around the vagina, usually in postmenopausal women. It is inserted vaginally (using a special applicator).

Estradiol Vaginal Cream Side Effects

As with any medicine, estradiol vaginal cream can cause side effects. However, not everyone who uses the medication will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider. Serious side effects are less common.
Common side effects of estradiol vaginal cream include, but are not limited to:
  • Headaches
  • Breast tenderness
  • Irregular vaginal bleeding or spotting
  • Abdominal (stomach) cramps or bloating
  • Nausea and vomiting.
(Click Side Effects of Estradiol Vaginal Cream to learn more, including potentially serious side effects that you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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