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If you are a woman who experiences heavy menstrual bleeding, your healthcare provider may recommend Lysteda, the first nonhormonal drug approved for this use in the United States. The medicine comes in tablet form and is taken three times a day for up to five days during your period. Commonly reported side effects include headache, sinus symptoms, and back pain.

What Is Lysteda?

Lysteda™ (oral tranexamic acid) is a prescription medication approved to treat heavy menstrual bleeding. It is the first nonhormonal medication approved for this use in the United States.
(Click Lysteda Uses for more information, including possible off-label uses.)

Who Makes It?

This medication is made by Mikart, Inc., for Ferring Pharmaceuticals, Inc.

How Does Lysteda Work?

Lysteda is an antifibrinolytic medication -- this means that it inhibits the process of fibrinolysis (the breakdown of blood clots). Blood clots are largely made of a protein called fibrin. An enzyme known as plasmin is responsible for breaking down the clots. Lysteda works by preventing the enzyme plasmin from being formed and by preventing plasmin from binding to the fibrin in the clots, which prevents the clots from breaking down.
Since heavy menstrual bleeding has been associated with an abnormally high rate of clot breakdown, Lysteda can help decrease excess menstrual bleeding.

When and How to Take It

General considerations to keep in mind during treatment with Lysteda include the following:
  • This medication comes in tablet form. It is usually taken by mouth three times a day for up to five days during your menstrual period.
  • Lysteda can be taken with or without food. Try taking it with food if it bothers your stomach.
  • Do not crush, chew, or break the tablets; be sure to swallow them whole.
  • For the medication to work properly, it must be taken as prescribed.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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