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The main uses of Macrodantin are to treat and to prevent urinary tract infections (UTIs). Macrodantin is particularly effective for bladder infections caused by E. coli, S. saprophyticus, and certain other bacteria. Although this antibiotic can be used in children as young as one month, it is not always the treatment of choice in such young children; a liquid antibiotic is typically used instead.

What Is Macrodantin Used For?

Macrodantin® (nitrofurantoin macrocrystalline) is a prescription antibiotic approved for the treatment and prevention of urinary tract infections (UTIs). Specifically, Macrodantin is used to treat and prevent bladder infections caused by the two most common types of UTI bacteria (Escherichia coli and Staphylococcus saprophyticus), as well as a few other types of bacteria.
This drug is not approved to treat kidney infections.

How Does It Work?

Macrodantin works in a unique way, compared to other antibiotics. In bacterial cells, the drug is changed into a highly reactive form that destroys certain bacterial proteins and molecules. As a result, the drug interferes with bacteria's ability to make essential cell components such as protein, DNA, and cell walls.

Can Children Use Macrodantin?

Macrodantin is approved for use in children over the age of one month, although the liquid form of nitrofurantoin (Furadantin®) is more suitable for very young children. Nitrofurantoin (in any form, including Macrodantin) should not be given to newborns (one month or younger) due to the risk of hemolytic anemia, a potentially dangerous condition involving the destruction of red blood cells.

Off-Label Uses of Macrodantin

On occasion, your healthcare provider may recommend this medicine for something other than the uses discussed in this article. At this time, there are no universally accepted off-label Macrodantin uses.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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