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Macrodantin is a drug used for treating and preventing urinary tract infections (UTIs). This prescription antibiotic works by interfering with the ability of bacteria to make certain cell components, such as DNA and protein. Available in the form of a capsule, this product is typically taken four times a day. Common side effects include vomiting, nausea, and loss of appetite.

What Is Macrodantin?

Macrodantin® (nitrofurantoin macrocrystalline) is a prescription antibiotic approved to treat and prevent urinary tract infections (UTIs).
(Click Macrodantin Uses for more information, including possible off-label uses.) 

Who Makes It?

Currently, brand-name Macrodantin is made by Procter & Gamble Pharmaceuticals, Inc. Generic versions are made by various manufacturers.

How Does Macrodantin Work?

Macrodantin works in a unique way, compared to other antibiotics. In bacterial cells, the drug is changed into a highly reactive form that destroys certain bacterial proteins and molecules. As a result, the drug interferes with bacteria's ability to make essential cell components such as protein, DNA, and cell walls.

When and How Do I Take It?

Considerations to keep in mind when taking this drug include the following:
  • The medication comes as a capsule that is usually taken four times daily, although it may be taken just once a day for long-term UTI prevention.
  • Macrodantin should be taken with food, as food increases the absorption of this antibiotic.
  • It does not matter what times of day you take this medication. However, try to space the doses out evenly per day, as reasonably as possible.
  • For Macrodantin to work properly, you have to take it as prescribed. It will not work adequately if you stop taking it too soon.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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