Women Home > Drug Interactions With Medroxyprogesterone Intramuscular Injection

If certain drugs are used in combination with medroxyprogesterone intramuscular injection, negative interactions may occur. Some of these reactions, such as with antibiotics or retinoids, can decrease the effectiveness of medroxyprogesterone. Other reactions may cause loss of bone density or other potentially serious side effects. To help minimize any complications, tell your healthcare provider about any other medicines, vitamins, or supplements you are taking.

An Overview of Medroxyprogesterone Intramuscular Injection Interactions

Medroxyprogesterone intramuscular injection (Depo-Provera®) may potentially interact with a number of other medications. Some of the drugs that can lead to interactions with medroxyprogesterone intramuscular injection include but are not limited to:
  • Antibiotics
  • Certain anti-seizure medications, such as:
  • Corticosteroids, such as:
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
  • Griseofulvin (Grifulvin V®)
  • Protease inhibitors, such as:
  • Retinoids, such as:
  • Tranexamic acid (Cyklokapron®, Lysteda®).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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