Women Home > Medroxyprogesterone Intramuscular Injection Side Effects

Although most side effects of medroxyprogesterone intramuscular injection tend to be minor, contact your healthcare provider immediately if you develop potentially serious problems, such as a severe headache, changes in vision or speech, or seizures. Some common reactions to this drug include weight gain, headaches, and irregular menstrual bleeding.

An Introduction to Side Effects of Medroxyprogesterone Intramuscular Injection

Just like any medicine, medroxyprogesterone intramuscular injection (Depo-Provera®) can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with medroxyprogesterone intramuscular injection. Your healthcare provider can discuss a more complete list with you.)

Serious Medroxyprogesterone Intramuscular Injection Side Effects

Some side effects of medroxyprogesterone intramuscular injection are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
    • Vision or speech changes
    • Weakness or numbness in an arm or leg
    • A severe headache
  • Signs of a blood clot in the lung, such as:
    • Shortness of breath
    • Sudden chest pain
    • Coughing up blood
  • Signs of a blood clot in the leg, such as severe pain or swelling of the calf
  • Severe abdominal (stomach) pain
  • Signs of liver damage, such as:
    • Yellowing of the whites of the eyes or skin (jaundice)
    • Dark urine
    • Upper-right abdominal (stomach) pain
  • Seizures
  • Depression
  • Persistent abnormal menstrual periods or heavy vaginal bleeding
  • Injection site reactions, such as severe or persistent pain, pus, or bleeding
  • A change in blood glucose levels, especially if you have diabetes
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Difficulty breathing or swallowing.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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