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Many medications can cause potentially dangerous drug interactions with milnacipran, including lithium, St. John's wort, linezolid, and tramadol. These interactions may increase your risk for developing a group of symptoms called serotonin syndrome (such as fever, hallucinations, and muscle spasms). In order to help prevent interactions, make sure to tell your healthcare provider about all other medications you are taking.

Milnacipran Interactions: An Overview

Milnacipran hydrochloride (Savella®) can potentially interact with a number of other medications. Some of the medicines that may lead to drug interactions with milnacipran include but are not limited to:
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
  • Monoamine oxidase inhibitors (MAOIs), such as:
  • Other SSRI or SNRI antidepressants, such as:
    Written by/reviewed by:
    Last reviewed by: Kristi Monson, PharmD;
    Last updated/reviewed:
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