Women Home > Milnacipran
You should talk with your healthcare provider prior to taking milnacipran if you have:
- Bipolar disorder or a family history of bipolar disorder (also known as manic depression)
- A history of suicide attempts or suicidal thoughts
- High blood pressure (hypertension)
- Seizures or epilepsy
- Glaucoma (a condition of the eyes)
- Liver disease, including liver failure or cirrhosis
- Bladder or prostate problems
- A bleeding disorder
- Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see Savella and Pregnancy)
- Breastfeeding (see Savella and Breastfeeding).
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Milnacipran to learn more, including information on who should not take the drug.)
Milnacipran is part of a class of drugs called serotonin-norepinephrine reuptake inhibitors, or SNRIs for short. SNRIs affect specific chemicals within the brain known as serotonin and norepinephrine. These are two of several chemicals used to send messages from one nerve cell to another.
As a message travels down a nerve, it causes the end of the cell to release serotonin or norepinephrine. The serotonin or norepinephrine enters the gap between the first nerve cell and the one next to it. When enough reaches the second nerve cell, it activates receptors on the cell, and the message continues on its way. The first cell then quickly absorbs any serotonin or norepinephrine that remains in the gap between the cells. This is called "reuptake."
Although milnacipran is an SNRI medication, it is not entirely clear how it works for fibromyalgia pain.