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You may be advised to avoid drinking alcohol and taking certain medications while using orally disintegrating phentermine. This is because some drug interactions with this weight loss product may lead to serious and even life-threatening complications. Medications that may cause interactions include guanethidine, diabetes medications, and MAOIs, among others. Talk to your healthcare provider about the specific interactions that may apply to you.

An Overview of Orally Disintegrating Phentermine Interactions

Orally disintegrating phentermine (Suprenza™) may interact with a few other medications. Some of the drugs that may react with orally disintegrating phentermine include but are not limited to:
  • Alcohol
  • Guanethidine (Ismelin®)
  • Medications used to treat diabetes
  • Monoamine oxidase inhibitors (MAOIs), such as:

More Detail on Drug Interactions With Orally Disintegrating Phentermine

The following sections explain in detail the potentially negative reactions that can occur when orally disintegrating phentermine is combined with any of the drugs listed above.
People who are using orally disintegrating phentermine are usually advised to avoid drinking alcohol.
Orally disintegrating phentermine may decrease the effectiveness of guanethidine at lowering blood pressure. If you take guanethidine, make sure your healthcare provider knows before using orally disintegrating phentermine.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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