Women Home > Ospemifene Side Effects

Some of the possible side effects of ospemifene include vaginal discharge, hot flushes, and muscle spasms. However, studies have shown that most women who use this drug tolerate it fairly well. In some cases, ospemifene is associated with potentially serious problems, such as strokes, blood clots, and allergic reactions, so let your healthcare provider know immediately if you develop something that doesn't seem right.

An Introduction to Side Effects With Ospemifene

As with any medicine, ospemifene (Osphena™) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most women tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with ospemifene. Your healthcare provider can discuss a more complete list with you.)

Serious Ospemifene Side Effects

Some side effects of ospemifene should be reported immediately to your healthcare provider. These include but are not limited to:
  • Unusual vaginal bleeding
  • Signs of a stroke, such as sudden:
    • Changes in vision or speech
    • Weakness or numbness of the face, arm, or leg
    • Severe headache
    • Confusion or loss of coordination or balance
  • Signs of a blood clot, such as:
    • Shortness of breath
    • Sharp chest pain
    • Pain or swelling in one or both legs
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth, lips, or throat
    • Wheezing
    • Difficulty breathing or swallowing.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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