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If you have gone through menopause and experience painful sexual intercourse, your healthcare provider may recommend ospemifene. This prescription tablet is taken once daily to help alleviate vaginal dryness and thinning, which can cause painful intercourse. Although most women tolerate the medication well, side effects are possible and may include vaginal discharge, muscle spasms, and hot flushes.


What Is Ospemifene?

Ospemifene (Osphena™) is a prescription medication approved to treat painful intercourse, known medically as dyspareunia, in women who have gone through menopause. It belongs to a group of medicines known as selective estrogen receptor modulators (SERMs).
(Click What Is Ospemifene Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, ospemifene can cause side effects. However, not everyone who uses the drug will experience problems. Most women tolerate it quite well.
If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious side effects are less common.
Common side effects of ospemifene include but are not limited to:
  • Hot flushes
  • Vaginal discharge
  • Muscle spasms.
(Click Ospemifene Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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