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Prostin E2 is used to cause an abortion or to remove a fetus that has died in the womb but has not naturally miscarried. This prescription medicine works by softening and relaxing the cervix, as well as causing the uterus to contract. It comes as a suppository that is inserted high into the vagina. Side effects may include vomiting, headaches, and diarrhea.

What Is Prostin E2?

Prostin E2® (dinoprostone vaginal suppository) is a prescription medication approved to cause an abortion or to remove any contents remaining in the womb (the uterus) after a "missed abortion" or "missed miscarriage" (when a fetus dies in the womb but is not naturally miscarried as normal). It is also approved to treat a cancer-like condition of the uterus known as gestational trophoblastic disease.
Prostin E2 contains dinoprostone, a hormone-type substance found naturally in the body. Cervidil® (dinoprostone vaginal insert) and Prepidil® (dinoprostone vaginal gel) contain lower doses of dinoprostone. They are used to prepare the cervix for induction of labor.
(Click Prostin E2 Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Prostin E2 is made by Pharmacia and Upjohn Company, a division of Pfizer, Inc.

How Does Prostin E2 Work?

Prostin E2 is a manufactured (synthetic) version of prostaglandin E2, a natural substance made by the body. Prostaglandin E2 is naturally secreted by the fetus and placenta during pregnancy. It plays an important role in the steps leading to labor by relaxing and softening the cervix to allow passage of the baby and increasing contractions. Like naturally occurring prostaglandin, Prostin E2 causes the uterus to contract and push out the contents of conception, including the fetus and placenta.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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