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Drug interactions with sibutramine are possible if it is taken with certain other medications, such as some pain medications; cough cold, or allergy medications; and other weight-loss medications. Some of these drug interactions with sibutramine can affect the level of medications in your blood, possibly increasing your risk of side effects or decreasing the effectiveness of the medications. To avoid these interactions, tell your healthcare provider about any other medications you are taking prior to starting sibutramine.

An Introduction to Drug Interactions With Sibutramine

In October 2010, sibutramine hydrochloride was withdrawn from the market in the United States. Studies have shown that it increases the risk of heart attacks and strokes. This medication will no longer be available in the United States. People should stop taking it and should ask their healthcare providers about more appropriate weight loss options.
Sibutramine hydrochloride monohydrate (Meridia®) can potentially interact with a few other medicines. Some of these medicines that may lead to sibutramine interactions include:
  • Certain antibiotics or antifungal medications
  • Certain pain medications, including:
  • Cough, cold, or allergy medications
  • Ergot medications, such as:
    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergonovine
    • Ergotamine (Cafergot®, Ergomar®)
    • Methylergonovine (Methergine®)
    • Pergolide (Permax®
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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