Women Home > Vandazole Warnings and Precautions

Before you begin treatment with Vandazole, make sure your healthcare provider knows if you consume alcohol often or if you have any allergies. In cases such as these, Vandazole may not be the best treatment option for your situation. Other important precautions for using Vandazole safely include warnings of potential drug interactions, yeast infections, and other potentially serious complications.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using Vandazole® (metronidazole vaginal gel) if you:
  • Have any allergies, including to medications, foods, dyes, or preservatives
  • Frequently consume alcohol
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Vandazole

Some warnings and precautions to be aware of prior to using this medication include the following:
  • Vandazole is for vaginal use only. Do not swallow it, and make sure to keep it out of your eyes. If you accidentally get some of the gel in your eyes, flush your eyes with large amounts of cool tap water.
  • In rare cases, some people have had seizures or developed peripheral neuropathy due to oral or intravenous (IV) metronidazole, the active ingredient in Vandazole. Thus, such problems are at least theoretically possible with Vandazole. Signs of peripheral neuropathy typically include unusual sensations, such as burning, tingling, or pricking in the extremities (the hands, lower legs, and feet). Let your healthcare provider know if you develop any such problems.
  • The standard advice is that women using metronidazole products should not drink alcohol. However, this type of interaction is probably less likely to occur when metronidazole is applied vaginally, as it is with Vandazole. It should be noted that there is some uncertainty about the validity of this interaction (see Metronidazole and Alcohol). Officially, the prescribing information for Vandazole states that women should stop consuming alcohol during treatment with this product and for at least three days after the last dose.
  • Combining metronidazole and disulfiram (Antabuse®) can cause psychosis, such as hallucinations. However, it is unclear if this interaction applies to the vaginal formulations of metronidazole, such as Vandazole, as only a small amount of the medication is absorbed into the bloodstream. Check with your healthcare provider before using these medications together. The prescribing information for Vandazole recommends not using the medication if you have taken disulfiram within the past two weeks.
  • Do not have sex while you are being treated with Vandazole. Also, do not use any other vaginal products, such as tampons or douches, during treatment.
  • Be aware that up to 12 percent of women develop vaginal yeast infections during or immediately after treatment with Vandazole. Such infections need to be treated, as Vandazole is not effective against yeast infections.
  • The active ingredient in Vandazole passes through breast milk. Therefore, if you are breastfeeding or plan to start, check with your healthcare provider (or your child's healthcare provider) before using this product (see Vandazole and Breastfeeding).
  • Vandazole is a pregnancy Category B medication, which means that it is probably safe for use during pregnancy, although the full risks are currently unknown (see Vandazole and Pregnancy for more information). Although Vandazole is not approved for use in pregnant women, it may sometimes be prescribed off-label to pregnant women.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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