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Macrodantin and Breastfeeding

In most cases, breastfeeding while taking Macrodantin (nitrofurantoin macrocrystalline) is considered safe. However, this medication is not recommended for all nursing women. For example, if your child is under one month old or has glucose-6-phosphate dehydrogenase deficiency, you should not breastfeed while taking this drug.

Is Macrodantin Safe for Breastfeeding Women?

Macrodantin® (nitrofurantoin macrocrystalline) passes through breast milk in humans. However, in most circumstances, it is considered safe for use while breastfeeding. Nonetheless, if you are nursing a child, you should talk with your healthcare provider before taking Macrodantin. Breastfeeding women can be assured that this is one of the most commonly prescribed antibiotics for urinary tract infections in women who are nursing.

What Does the Research Say?

Studies have shown that Macrodantin passes through breast milk in trace amounts. However, this does not seem to be a problem for most women or their infants.
There are a few potential problems, though. Like all antibiotics, Macrodantin can disrupt the normal "good" bacteria, which can lead to diarrhea, thrush, or other problems. This could occur in an infant exposed to Macrodantin through breast milk.
Macrodantin and other forms of nitrofurantoin are some of the most commonly used antibiotics for treating urinary tract infections in breastfeeding women. However, this drug should be avoided if you are nursing a newborn (one month or younger) or if your child has glucose-6-phosphate dehydrogenase deficiency, as exposure to this drug could increase the risk of hemolytic anemia (destruction of red blood cells).

Talking With Your Healthcare Provider About Breastfeeding and Macrodantin

You should discuss Macrodantin and breastfeeding with your healthcare provider. Each woman's situation is different, and you and your healthcare provider understand your situation best. After considering what you want and expect, as well as your current health situation, the two of you can make a shared decision that is right for you. In general, this medication is considered safe for nursing women and their infants.
Last reviewed by: Kristi Monson, PharmD
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