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Macrodantin Drug Interactions

Certain medications (such as Probenecid and oral typhoid vaccine) can react with Macrodantin. When drugs interact with Macrodantin, a number of problems can result, such as decreased effectiveness or a change in the way the body absorbs Macrodantin. Before starting treatment with this antibiotic, tell your healthcare provider about all medications you currently take.

An Overview of Interactions With Macrodantin

Macrodantin® (nitrofurantoin macrocrystalline) can potentially interact with a number of other medicines. The drugs that may lead to interactions with Macrodantin can include but are not limited to:

Macrodantin Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Macrodantin is taken with any of the drugs listed above.
Magnesium Trisilicate
If Macrodantin is taken with products containing magnesium trisilicate, your body may not absorb Macrodantin adequately. These medications should not be combined.
Norfloxacin
Macrodantin may make norfloxacin less effective. In general, these medications should not be taken together.
Oral Typhoid Vaccine
Macrodantin may decrease the effectiveness of the oral typhoid vaccine. If you are taking Macrodantin, your oral typhoid vaccine may need to be postponed for at least a day after finishing your Macrodantin prescription.
Probenecid
Probenecid can affect the way the kidneys handle Macrodantin. This can cause Macrodantin to build up in the bloodstream (possibly leading to toxicity) and may also make Macrodantin less effective.

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‣ Final Thoughts
Last reviewed by: Kristi Monson, PharmD
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