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Drug Interactions With Medroxyprogesterone Intramuscular Injection

CYP 3A4 Inducer Medications
The liver breaks down the hormones in medroxyprogesterone intramuscular injection using enzymes known as CYP 3A4 enzymes. Certain medications known as CYP 3A4 inducers can increase the activity of these enzymes. Combining medroxyprogesterone intramuscular injection with one of these CYP 3A4 inducers may decrease the level of medroxyprogesterone in your bloodstream, possibly making it less effective.
If you are taking medroxyprogesterone intramuscular injection as a contraceptive, talk to your healthcare provider about this interaction. You may need to use a different birth control method.
Griseofulvin
Griseofulvin may decrease the effectiveness of combination birth control pills (pills that contain estrogen and progestin). Although it is unknown if griseofulvin also affects medroxyprogesterone intramuscular injection, you may want to use another form of birth control if you are taking griseofulvin and also receiving medroxyprogesterone intramuscular injections.
Protease Inhibitors
Protease inhibitors can increase or decrease the level of medroxyprogesterone intramuscular injection in the bloodstream, which could increase the risk for side effects or make the medication less effective. Check with your healthcare provider before combining medroxyprogesterone intramuscular injection with a protease inhibitor.
Retinoids
Retinoids may decrease the effectiveness of progestin-only birth control pills. It is unknown if retinoids affect medroxyprogesterone intramuscular injection in the same way. If you are using medroxyprogesterone intramuscular injection as a form of contraception, talk to your healthcare provider about this potential interaction. You may need to use a different birth control method.
Last reviewed by: Kristi Monson, PharmD
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