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Medroxyprogesterone Intramuscular Injection Dosage

When using medroxyprogesterone intramuscular injection, the dosage your healthcare provider prescribes will be based on the reason you are using this drug and how you respond to it. The standard dose for pregnancy prevention is 150 mg injected every three months. To relieve symptoms of certain types of cancer, the initial dosage can range from 400 mg to 1000 mg injected every week.

An Introduction to Your Dosage of Medroxyprogesterone Intramuscular Injection

The dose of medroxyprogesterone intramuscular injection (Depo-Provera®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The reason you are receiving medroxyprogesterone intramuscular injection
  • How you respond to the medication.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Medroxyprogesterone Intramuscular Injection Dosing for Pregnancy Prevention

The standard dose of medroxyprogesterone intramuscular injection for preventing pregnancy is 150 mg every 3 months (13 weeks). The first injection should only be given at a time when pregnancy is not a possibility. These times include:
  • The first five days of the menstrual period
  • The first five days after birth in women who are not breastfeeding
  • The sixth week after birth in women who are breastfeeding.
Medroxyprogesterone intramuscular injection is most effective if given every 13 weeks. If more than 13 weeks have passed since the last shot, pregnancy should be ruled out again before another dose is given.
If you are switching from oral contraceptives to medroxyprogesterone intramuscular injection, you should receive your first shot after taking your last active pill, but before you take your last inactive pill. If you are switching from another form of birth control to medroxyprogesterone intramuscular injection, your healthcare provider will determine when you should receive your first shot to ensure you have continuous birth control coverage.
Last reviewed by: Kristi Monson, PharmD
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