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Medroxyprogesterone Intramuscular Injection

How Does It Work?

Medroxyprogesterone intramuscular injection contains medroxyprogesterone, a manmade (synthetic) form of progesterone. Progesterone is a progestin hormone that plays a key role in the menstrual cycle. Medroxyprogesterone intramuscular injection prevents pregnancy by stopping ovulation (the release of an egg from the ovary). It also thins the endometrium (the lining of the uterus), preventing implantation (attachment of a fertilized egg to the wall of the uterus), and thickens the cervical mucus, making it more difficult for sperm to reach the egg.
Medroxyprogesterone intramuscular injection can also slow down the growth of cancer cells in people with endometrial or kidney cancer. However, it does not cure the cancer.

When and How to Receive This Medicine

Some general considerations to keep in mind during treatment with medroxyprogesterone intramuscular injection include the following:
  • This medication is given as an injection into a muscle, every week to every three months, depending on the reason it is being used.
  • The injection is usually given by a healthcare provider in a healthcare setting, such as a clinic. It is usually given in the buttocks (gluteal muscle) or upper arm (deltoid muscle).
  • Medroxyprogesterone intramuscular injection should not be used as a contraceptive for longer than two years, unless other birth control methods are not an option.
  • For this drug to work properly, it must be administered as prescribed. Make sure to keep all of your appointments with your healthcare provider to avoid missing a dose.

Storage Information

Medroxyprogesterone intramuscular injection should be stored at room temperature. It is normally stored by your healthcare provider. Make sure to keep this and all other medications out of the reach of children and pets.
Last reviewed by: Kristi Monson, PharmD
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