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Medroxyprogesterone Intramuscular Injection Side Effects

Common Side Effects

Medroxyprogesterone intramuscular injection has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people receiving medroxyprogesterone intramuscular injection were carefully documented. As a result, it was possible to see what side effects occurred and how often they appeared.
In these studies, common medroxyprogesterone intramuscular injection side effects included:
  • Irregular menstrual bleeding (such as spotting or an increase or decrease in bleeding) -- in up to 57.3 percent of people
  • Lack of a menstrual period (amenorrhea) -- up to 55.0 percent
  • Weight gain -- up to 37.7 percent
  • Headache -- up to 16.9 percent
  • Abdominal (stomach) pain or discomfort -- up to 11.2 percent
  • Nervousness -- up to 10.8 percent
  • Dizziness -- up to 5.6 percent
  • Decreased libido (sex drive) -- up to 5.5 percent.
Irregular menstrual bleeding will usually decrease over several months. Most women will eventually stop having periods with repeated use of medroxyprogesterone intramuscular injection.
Other common side effects, occurring in 1 to 5 percent of people, may include:
  • Fatigue or tiredness
  • Leg cramps
  • Nausea
  • Vaginal discharge
  • Breast pain or tenderness
  • Bloating or swelling
  • Back ache
  • Painful menstruation
  • Depression
  • Acne
  • Lack of hair growth
  • Rash
  • Vaginal itching and irritation
  • Insomnia
  • Joint pain
  • Hot flashes.

Final Thoughts

You may experience some or none of the side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects while using medroxyprogesterone intramuscular injection or if something "just does not seem right." While it may not be related to the medication, your healthcare provider will be able to diagnose and treat the problem.
Last reviewed by: Kristi Monson, PharmD
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